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Algunos estudios exploratorios en humanos han reportado rangos de 200500 g/da, pero la calidad metodolgica es variable y no constituye un consenso clnico

ChaC2 is a constitutively expressed protein whose expression is not affected by the external environment for the basal turnover of GSH [37]

It accumulates as unmetabolized folic acid (UMFA) and competes with active folates for receptors. Conversion between the two active forms is unreliable : it requires multiple enzymes (MTR, MTRR, SHMT, MTHFR, MTHFS) all working properly, and is easily blocked by low glutathione, B12 deficiency, heavy metals, or oxidative stress

Six children suffering from radiation-induced GHD treated with GH between 3 and 10 years after cranial irradiation exhibit a mean growth during the pretreatment year of 3.7 cm and during the first year of GH therapy is 7.9 cm, indicating the recovery effect of GH on radiation damage (Shalet et al., 1981)

Indian J Clin Biochem 30(1):11